The best pain relief (2024)

Most adults have experienced serious pain at some point in their lives. For some of you, managing pain may even be one of your primary health concerns. Long-term daily pain affects 25 million Americans, and 14.4 million people suffer from category 4 pain, the highest level. Pain can be disabling, affecting your ability to work, care for your family, manage other health conditions and enjoy life. So it’s no surprise that, when it comes to pain relief, sufferers want the best of the best.

Given all the headlines about opioids, you may believe they’re the strongest pain drugs available. And you’re likely concerned about taking something known to be highly addictive. But according to pain specialists, opioids are not a silver bullet for all kinds of pain. In fact, non-opioid alternatives can be even more effective.

The modern approach to pain management often involves combination therapy that attacks it from different angles. This is your guide to the best non-opioid treatments for four common causes of pain: dental procedures, lower back problems, nerve pain (neuropathy) and migraine.

1. Painkillers for tooth extraction and oral surgery.

Because dental pain is often caused by swelling and inflammation, anti-inflammatories are especially effective. Many patients find that ibuprofen, a non-steroidal anti-inflammatory (NSAID), is all they need. In cases where ibuprofen alone is not enough, studies show that a combination of ibuprofen (Advil, Motrin) and acetaminophen (Tylenol) actually works better than opioids following dental surgery.

Another option to discuss with your dentist is Exparel, an injection that numbs the area being worked on. Unlike other local anesthetics, Exparel continues to suppress pain for up to 72 hours. Aetna is the first and only dental insurer to cover Exparel for wisdom tooth extractions and other common surgeries, including hernia and breast cancer.

2. Treatments for lower back pain.

For chronic pain, it’s important to address the root cause as well as the role stress plays in magnifying pain. People with lower-back problems, for instance, benefit most from a treatment plan that includes medication plus physical therapy, acupuncture and/or cognitive behavioral therapy­.

Research shows that opioids, though effective at blocking short-term pain signals, don’t offer much help for people with chronic pain. That’s because opioids become less effective the longer you take them.

3. Easing pain from neuropathy.

Patients with certain health conditions ― diabetes, multiple sclerosis, fibromyalgia, shingles ― can suffer from a type of nerve pain called peripheral neuropathy. In these cases, over-the-counter medication and non-drug approaches (massage, dietary supplements) may be combined with antidepressants. That doesn’t mean the pain is all in your head.Antidepressants work on a number of neurotransmitters (the chemical messengers used by the nervous system) that can be involved in pain.

4. Migraine prevention and relief.

Migraine is more than a headache. It’s often accompanied by nausea, dizziness and vision problems. The cause is unknown, but some experts believe it’s a genetic disorder of the central nervous system that may be related to epilepsy. Doctors typically recommend triptans, a medication that works on serotonin receptors, and NSAIDs. Frequent migraine may call for preventive measures, such as dietary changes, blood pressure medication or anti-seizure drugs.

Although opioids do block migraine pain, they can also lead to more severe and frequent headaches. It’s easy to see how that can become a vicious cycle.

For some people, opioids are essential medicines. They provide better quality of life for patients with acute severe pain, cancer pain or pain at end-of-life. We don’t want to take opioids away from people who really need them. At the same time, opioids are routinely overprescribed for conditions they were not intended to treat.

If you experience chronic pain or have a surgical procedure in your future, have a conversation with your primary doctor or a pain specialist. In the event your doctor or dentist offers to prescribe opioids, let them know you’re open to non-opioid treatments. Aetna’s Find a Doctor toolallows members and nonmembers to search for surgeons that offer non-opioid pain relief options.

You may be pleasantly surprised by just how effective non-opioids can be.

About the author

Dr. Paz is Aetna’s executive vice president and chief medical officer. In that role, he leads policy decisions and drives innovations to improve patient experience. He is trained as a pulmonologist, a specialist who focuses on people with lung conditions.

The best pain relief (2024)

FAQs

What is the no. 1 for pain relief? ›

Acetaminophen. Acetaminophen is usually recommended as a first line treatment for mild to moderate pain. It might be taken for pain due to a skin injury, headache, or conditions that affect the muscles and bones. Acetaminophen is often prescribed to help manage osteoarthritis and back pain.

What is best for extreme pain? ›

Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen – these medicines relieve pain and reduce inflammation (redness and swelling). Opioid medicines, such as codeine, morphine and oxycodone – these medicines are reserved for severe or cancer pain.

What is the strongest natural painkiller? ›

  1. Lavender essential oil. Lavender essential oil may help relieve pain naturally. ...
  2. Rosemary essential oil. Rosemary is another essential oil that may relieve pain. ...
  3. Peppermint essential oil. Peppermint oil comes from the Mentha piperita L. plant. ...
  4. Eucalyptus essential oil. ...
  5. Cloves. ...
  6. Capsaicin. ...
  7. Ginger. ...
  8. Feverfew.

What stops nerve pain immediately? ›

Painkillers. For severe nerve pain, powerful opioid painkillers can help. Studies have found that for many types of nerve pain, they are as effective as anticonvulsants or antidepressants. Unlike other treatments for nerve pain, they also work very quickly.

What are the top 3 pain relievers? ›

Ibuprofen (Advil, Motrin), aspirin/citric acid/sodium bicarbonate (Alka-Seltzer), naproxen (Aleve), acetaminophen (Tylenol), and aspirin are some of the top-rated over-the-counter (OTC) pain relief medications.

Which painkiller is best for long-term use? ›

Acetaminophen is considered the safest OTC painkiller for long-term use because it's thought to have fewer side effects than the other options. Nevertheless, people respond differently to different medications. If the first one doesn't help, work with your doctor to find one that does.

What is the ultimate pain killer? ›

Fentanyl: Fentanyl is a synthetic opioid and is said to be 30 to 50 times stronger than heroin. This prescription medication is used to treat severe pain after surgery and chronic pain in opioid-dependent people.

How do I stop unbearable pain? ›

10 ways to reduce pain
  1. Get some gentle exercise. ...
  2. Breathe right to ease pain. ...
  3. Read books and leaflets on pain. ...
  4. Talking therapies can help with pain. ...
  5. Distract yourself. ...
  6. Share your story about pain. ...
  7. The sleep cure for pain. ...
  8. Take a course.

What drug takes away extreme pain? ›

Pain medications - narcotics
  • Codeine.
  • Fentanyl -- available as a patch, lozenge, or lollipop.
  • Hydrocodone.
  • Hydromorphone.
  • Meperidine.
  • Morphine.
  • Oxycodone.
  • Tramadol.
Apr 27, 2023

What is the best all round painkiller? ›

Naproxen. Naproxen (Aleve) is the most powerful anti-inflammatory pain reliever available without a prescription. It is especially effective for sprains, sunburns and arthritis and other conditions. Similar doses of Naproxen tend to last longer than other non-prescription pain relievers.

Which painkiller works the fastest? ›

Best for Quick Action. Ibuprofen is a short-acting NSAID that starts working faster than naproxen. 11 This may be better for acute pain, like a new injury. The downside is that ibuprofen has to be taken more often than naproxen.

What is the strongest nerve pain medication? ›

Anticonvulsants are one of the most effective medications for treating nerve pain. Examples include pregabalin (Lyrica) and gabapentin (Neurontin). These medications are typically very effective in treating nerve pain, but they may also cause undesired side effects, such as: lethargy.

What is the best drink for nerve pain? ›

Water reduces nerve stress, and it can help to relax muscles. That can mean reduced pain, healthier nerves, and faster recovery from nerve damage. Be sure to drink plenty of water alongside your diet to keep your body and nerves hydrated.

What is the safest pain reliever for seniors? ›

Acetaminophen (Tylenol) is usually safer for older adults than other pain medicines. Topical pain medicines (also called topical analgesics) can also help. When common pain medicines don't work to manage pain, your healthcare provider may suggest other medicines, such as antidepressants or anticonvulsants.

What do neurologists prescribe for nerve pain? ›

What types of medicine are used for nerve pain?
  • antidepressant medicines such as amitriptyline and duloxetine (usually used at lower doses than those to treat depression)
  • anti-seizure medicines including gabapentin and pregabalin.

What is the number one pain medication? ›

Top pain medications prescribed and dispensed in 2022
RankDrug nameExplore dataset
1Hydrocodone-AcetaminophenExplore
2IbuprofenExplore
3Tramadol HclExplore
4Oxycodone-AcetaminophenExplore
6 more rows
Sep 8, 2023

What is the best product for pain relief? ›

Biofreeze Professional Pain Relief Gel is the best overall muscle pain relief cream due to its fast-acting and long-lasting formula. Its cooling menthol and camphor provide immediate relief by interfering with the body's pain signals, making it an ideal choice for quickly alleviating muscle soreness and discomfort.

What is prescribed for severe pain? ›

Pain medications - narcotics
  • Codeine.
  • Fentanyl -- available as a patch, lozenge, or lollipop.
  • Hydrocodone.
  • Hydromorphone.
  • Meperidine.
  • Morphine.
  • Oxycodone.
  • Tramadol.
Apr 27, 2023

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